|
KMID : 0359920120310010038
|
|
Korean Journal of Nephrology
2012 Volume.31 No. 1 p.38 ~ p.47
|
|
|
Association between vascular access failure and microparticles in hemodialysis patients
|
|
Ryu Jung-Hwa
Lim Soo-Young
Ryu Dong-Ryeol
Kang Duk-Hee
Choi Kyu-Bok
Kim Seung-Jung
|
|
|
Abstract
|
|
|
Background: Vascular access failure, a major cause of morbidity in hemodialysis (HD) patients, occurs mainly at stenotic endothelium following an acute thrombotic event. Microparticles (MPs) are fragments derived from injured cell membrane and are closely associated with coagulation and vascular inflammatory responses.
Methods: We investigated the relationship between levels of circulating MPs and vascular access patency in HD patients. A total of 82 HD patients and 28 healthy patients were enrolled. We used flow cytometry to measure endothelial MPs (EMPs) identified by CD31þCD42 or CD51þ and platelet-derived MPs (PMPs) identified by CD31þCD42þ in plasma samples of participants. Vascular access patency was defined as an interval from the time of access formation to the time of first access stenosis in each patient. MP counts were compared according to access patent duration.
Results: The levels of EMP (both CD31þCD42 and CD51þ) and CD31þCD42þPMP were significantly higher in patients than in healthy participants. Levels of CD31þCD42EMP and CD31þCD42þPMP showed a positive correlation. In nondiabetic HD patients, CD31þCD42EMPs and CD31þCD42þPMPs were more elevated in the shorter access survival group (access survival o1 year) than in the longer survival group (access survival Z 4 years).
Conclusion: Elevated circulating EMP or PMP counts are influenced by end-stage renal disease and increased levels of EMP and PMP may be associated with vascular access failure in HD patients.
|
|
|
KEYWORD
|
|
|
Cell derived, Endothelial cells, Hemodialysis, Microparticles, Platelets, Vascular access failure
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|